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Potential signaling pathway through which notch regulates oxidative damage and apoptosis in renal tubular epithelial cells induced by high glucose

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Retinal ischemia-hypoxia induced by BRB impairment further triggers neovascularization and nonperfusion, which exacerbates oxidative stress dysregulation and iron metabolism imbalance, forming a vicious positive feedback loop between oxidative stress and BRB damage that accelerates DR pathogenesis and amplifies ferroptosis susceptibility via iron overload and lipid peroxidation

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OS has been implicated in the development and progression of numerous diseases in humans

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