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The brain, compared with other organs, is particularly prone to lipid peroxidation due to the abundance of unsaturated fats and redox-active transition metals

Concomitantly, expanded adipose tissue synthesizes and secretes huge amounts of cytokines and chemokines, collectively defined adipochemokines or adipokines, such as leptin, that promote infiltration of adipose tissue by macrophages with subsequent overproduction of RO(N)S and inflammatory cytokines, leading to adipose tissue inflammation (21, 22)

[11] Two magnesium ions function to stabilize the acylphosphate intermediate, facilitate binding of ATP, and activate removal of phosphate group from ATP

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doi: 10.1016/0024-3205(81)90374-x 199 GirottiAWThomasJPJordanJE

Erythrocytes play a crucial role in the regulation of eNOS-derived nitric oxide (NO) bioavailability, acting as scavengers of this critical vasodilator with an effect on vascular tone and blood flow [45]