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Melasma responds partially to glutathione

Phytother Res 33:919928

DC Animal husbandry and tissue harvesting from mouse-model experiments

However, excessive ROS generation may also contribute to oxidative injury, depending on the treatment protocol and underlying pathological state

Additionally, using Hydroquinone in combination with Tretinoin and Azelaic Acid may increase the risk of paradoxical hyperpigmentation or other unwanted side effects, particularly with prolonged or excessive use