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The system Xc- facilitates the transfer of extracellular cystine to intracellular glutamate in a 1:1 ratio, subsequently leading to the synthesis of GSH from intracellular cystine, supported by the functions of glutamatecysteine ligase (GCL) and glutathione (GSS) [64]

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It can remodel SNCA aggregates and is a promising medication for PD and other -synucleinopathies [108]

(A) After 24 h of incubation, HCT-116 cells were stained with Hoechst 33342, after which cell nuclei were observed under a microscope for detection of apoptosis

Evidence specific to glutathione is limited, but leaving a 2030 minute gap is a low-effort habit worth building anyway

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