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This aligns with earlier findings that thrombin is a critical therapeutic target for non-small-cell lung cancer, where its inhibition disrupts the formation of vasculogenic mimicry, a mechanism by which aggressive tumors form fluid-conducting channels independent of ECs [265]

Biochem Med 2008;18:331-41

Indeed, GSH covalently binds to some drug molecules in a GST-dependent manner leading to their cellular export and quenches reactive oxidative species often requiring for these compounds to act [27, 28]

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Step 3 Pigment-signal disruption: Tranexamic Acid blocks the specific cell-signalling pathway responsible for triggering excess melanin production, particularly relevant for stubborn or hormonally-influenced pigmentation