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Dr Emma Guymer, a rheumatologist at Monash Health, told Rheumatology Republic there had not been any large, randomised placebo-controlled trials looking at B12 supplementation in patients with fibromyalgia with or without B12 deficiency

The drug is recommended only when its benefits outweigh fetal or maternal health risks

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As high homocysteine is a risk factor for depression and low mood, lowering homocysteine with these B vitamins may be the link

Over time, tolerance to the medication does develop

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