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Notably, the extent of metabolic decline is inversely correlated with Beck Depression Inventory-II (BDI-II) scores, suggesting an association between impaired brain energetics and depressive symptom severity (119)

Moreover, intervention timing (e.g., around ovulation induction or fertility treatment cycles) should be evaluated for optimal immuno-metabolic impact

This is further validated in human PBMCs that AGEs-exposure promoted Th2 differentiation and pro-inflammatory responses involving activation of the RAGE and TLR4 signaling axes

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