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However, simple crossing of the SOD1G93A mice with mice overexpressing EAAT2 (to about a double of the normal level) resulted in an ALS model where the appearance of ALS signs and the onset of the motor neuron loss were only marginally delayed, with no effect on the final outcome [392]

People taking biologics have sometimes reported the following health problems, though these are rare: lymphoma certain blood disorders (bleeding, bruising) severe allergic reactions liver damage neurological problems, including numbness, weakness, tingling, or visual disturbances, such as blurred vision, double vision, or partial blindness Biologics offer an advantage in treating Crohns disease because these drugs specifically target the substances in your body that cause bowel inflammation