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5AM-1MQ OVERVIEW Category: Small Molecule / Selective Enzyme Inhibitor (NNMTi) How It Works: Selectively inhibits the Nicotinamide N-methyltransferase (NNMT) enzyme to increase cellular NAD+ levels and metabolic expenditure

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Large-scale, well-designed trials with proper randomization and blinding are needed to determine whether high-dose oral supplementation is as effective as intramuscular injection for increasing vitamin B 12 status and alleviating clinical symptoms of vitamin B 12 deficiency

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[151] During the 1920s, George Whipple discovered that ingesting large amounts of liver seemed to most rapidly cure the anemia of blood loss in dogs, and hypothesized that eating liver might treat pernicious anemia