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10.1100/2012/973436 Sci

PMC 2223905

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Small imbalances or weaknesses anywhere in this system create compensatory patterns that perpetuate injury

Tonic signalingconstitutive CAR signaling in the presence or absence of ligand engagementparticularly associated with 4-1BB costimulatory domainshas been shown to impair CAR-Treg stability and function