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Additional side effects include electrolyte imbalance, redness, fever, allergic reactions, fluid overload, hyponatremia, and low blood sodium

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Molecular models of voltage sensing

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For example, when cultured in selenium-deficient conditions, Jurkat cells (a human T cell model) exhibit increased spontaneous cell death [18], due to decreased expression of selenium-dependent antioxidant enzymes (i.e., selenoproteins) such as glutathione peroxidases (GPx) and thioredoxin reductases leading to excessive oxidative stress and eventually cell death