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GLP-1 agonists and tirzepatide achieve 1522% weight loss in clinical trials DSMES (Diabetes Self-Management Education and Support): ADA 2026 Recommendation 5.2 provide DSMES at diagnosis, annually, when complications develop, and at life transitions

Methods Animal preparation The animal care and experimental protocols conformed to the recommendations in the 8th Edition of the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (NIH, revised 2011) and were in accordance with the Animal Management Rules of China (Documentation 55, 2001, Ministry of Health, China)

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