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In clinical trials of Wegovy (FDA-approved semaglutide), participants achieved an average weight loss of approximately 15% over 68 weeks, with some participants achieving up to 20% with continued treatment and adherence, when combined with diet and exercise

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Community sources generally describe combining two GHRH analogs as redundant rather than synergistic both act on the same GHRH receptor, so a second analog adds little once an adequate dose of one saturates the response