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Ultimately, personalized nutritional strategies-incorporating genetic background, trace element status, and gut microbiota composition-represent a promising direction for the precise prevention and management of AITD ( Figure 1 )

10.3892/ijmm.2019.4188 244 ZhaoS.MugaboY.IglesiasJ.XieL.Delghingaro-AugustoV.LussierR.et al (2014)

Wikipedia Insulin-like Growth Factor 1 (IGF-1) Comprehensive overview of IGF-1 biology, receptor interaction, and cellular signalling

We recently described that 25% of GBM patients present genetic alterations in the genes encoding ser/gly synthesis enzymes [21], observing common PSPH amplifications (cBioPortal, TCGA PanCancer Atlas dataset) (Figure S1) [25]