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Trx-thioredoxin reductase (TrxR) axis works synergistically with PRDX to detoxify peroxides and maintain thiol homeostasis in proteins (Garcia et al., 2012)

Functional MET channels are required for aminoglycoside ototoxicity, and increased channel open probability during acoustic stimulation enhances drug entry ( Once inside, aminoglycosides accumulate within hair cells to concentrations that persist for months owing to high-affinity binding to phosphatidylinositol 4,5-bisphosphate ( Mitochondrial dysfunction Aminoglycosides preferentially localize to mitochondria by binding to the 12S ribosomal RNA, which is encoded by the mitochondrially encoded gene MT-RNR1

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J., Smyth, G

02 The causes of histamine intolerance In most cases, decreased activity or production of the histamine-degrading enzyme DAO is responsible for histamine intolerance (colloquially known as DAO deficiency or DAO disorder)

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