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Resultant free intracellular ARA is subsequently converted into certain prostaglandins (i.e., PGE 2 or PGF 2 ) via cyclooxygenase (COX) enzymes [532], and these prostaglandins can signal associated receptors in an autocrine and paracrine manner to up-regulate signalling associated with increases in muscle protein synthesis

A high neutrophil to lymphocyte ratio found in critically ill patients with COVID-19 is associated with excessive ROS levels, that promote a cascade of biological events driving pathological host responses

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This imbalance renders granulosa cells vulnerable to ferroptosis, which can impair estrogen synthesis and disrupt follicular development (40)

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