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Several investigations demonstrated a significant reduction of mental flexibility in OSA subjects (Verstraeten and Cluydts, 2004

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10.1073/pnas.1711235114 70 CersosimoM

The authors evaluated 62 clinical trials which reported following the KD, and only 25 had an acceptable ketogenic ratio

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When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991