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NRF2 has been shown to lead to the upregulation of the SSP and SHMT enzymes, through induction of ATF4 (DeNicola et al., Besides increasing NAD(P)H production, one-carbon flux induced by these oxygen and redox sensing pathways also contributes to the maintenance of the oxidative balance through generation of glutathione (Locasale, This evidence asserts that not only are one-carbon units important to maintain redox balance, but also that the master regulators of redox remodeling participate in regulating flux through one-carbon metabolism ensuring a feedback mechanism that keeps homeostasis (Figure 2)

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