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Clin Chem Lab Med (2003) 41:12818

The multi-omics characterization is in strong agreement with established pathomechanisms of Parkinson's disease, particularly with respect to mitochondrial dysfunction and protein degradation pathways

100 Therefore, as the astrocytic scar limits inflammation and protects adjacent healthy tissues, the potentially harmful effects of the astrocytic scar should be alleviated rather than preventing or eliminating the astrocytic scar

69 Although MCT2 mediates neuronal lactate uptake, its inhibition reduces pathological lactylation but also diminishes lactate-induced synaptic protein expression (eg, PSD95, GAP43), ultimately impairing memory consolidation

First, The peripheral nerve compression model employed in this study cannot fully replicate key pathological processes such as chronic dorsal root ganglion compression caused by lumbar disc herniation, necessitating further mechanistic validation through more comprehensive disease models in subsequent studies

S.ShivashankarG