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Those with pre-existing conditions such as irritable bowel syndrome (IBS), functional dyspepsia, or gastritis may be more prone to experiencing stomach upset from supplements generally, including B12 preparations

Choose citrate if you tend to be constipated

If megadoses of B12 have any benefit on weight loss, its probably a placebo effect, Wright says

Avoid the use of strong disinfectants on the apparatus

Vitamin B12 is attached to protein molecules in food and can only be absorbed by the body after being split from the protein by hydrochloric acid in the stomach

Its very plausible that a doctors concern regarding potential B12 toxicity may arise from the fact that elevated levels of B12 often indicate a serious underlying condition