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Proceedings of the National Academy of Sciences, 120 (29) e2305871120, e2305871120

These effects suggest potential applications in peripheral neuropathies and traumatic nerve injuries, though human efficacy data remains limited

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It usually does not go away on its own, but some improvement can occur with age

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization

J Exp Med (2009) 206(8):167380