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However, they are crucial for individuals who: Have Diagnosed Vitamin B12 Deficiency : Those diagnosed with a deficiency confirmed through blood tests may require initial high doses through injection to restore levels

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For the initial B12 injection, I typically administer a 25-mg mixture of B12 in a 10cc formulation, with an equal mix of hydroxocobalamin and methylcobalamin

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In yeast, PUS7p deficiency has been shown to reduce the stability of -containing transcripts during heat shock [100]