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Author response: We have altered the phrasing to read, Adult wildtype C57BL6/J mice were injected with TAM or matched dose (ml/kg) of vehicle (oil) for 5d. Reviewer 1 In regard to an issue raised by Reviewer 2 (below) I question whether the estrous cycle would need to be tracked

Unlike oral supplements that may have absorption issues, B12 injections deliver the vitamin directly into the bloodstream, allowing for faster and more effective results

It supports nerve regeneration and may significantly reduce symptoms in conditions such as diabetic neuropathy or peripheral nerve disorders

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Understanding the reconstitution process gives you confidence in preparing your own medication and taking control of your weight loss journey

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