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Under neuroinflammatory conditions, curcumin (5-25 M) can attenuate LPS-induced microglial activation, achieving approximately 60% reduction in pro-inflammatory cytokine release (TNF-, IL-1, IL-6) by suppressing the TLR4/MyD88/NF-B signaling cascade ( 3.3 T cell Curcumin demonstrates significant immunomodulatory capacity in T cell-mediated diseases through pleiotropic mechanisms targeting cellular activation, differentiation, and effector functions