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These are given every 12 weeks initially, then monthly depending on the severity and cause of deficiency

BH4 not only takes part in numerous central metabolic processes by serving as an important cofactor for various enzymes (96), but also downregulates the oxidative degradation of phospholipids contained two PUFA tails by serving as a direct antioxidant and an important regulator in CoQ 10 synthesis (94), thus inhibiting lipid peroxidation and inducing ferroptosis

miR-142-3p impairs the expansion and function of nTregs by downregulating the autophagy-related protein ATG16L1 at both the mRNA and protein levels [82]

After infection, all mice were single-caged to prevent transfer of disease between mice and allow for appropriate diarrhea scoring