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Given that the degradation of KEAP1 encompasses two distinct pathways, namely autophagy 29 and proteasomal degradation 30 , we employed the protein synthesis inhibitor cycloheximide (CHX), the proteasome inhibitor MG132, and the autophagy inhibitor chloroquine (Chlq) to further explore the underlying mechanism in macrophages (Fig

The QCN-HS also exhibited histological evidence of dermal repair, including reduced inflammatory infiltration, organized collagen deposition, and enhanced vascular density, supporting the observed molecular changes

Cell culture Raw 264.7 cells (murine mononuclear macrophage cell line) were kindly provided by Cell Bank/Stem Cell Bank, Chinese Academy of Sciences

(109) Nakao, A

10.1038/d41586-019-03122-1 60 JaschkeN

It inhibits the absorption of cholesterol