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In other words, long-term calorie restriction doesnt appear to directly reduce serum IGF-1 in humans (18)

While IGF-1 (Insulin-like Growth Factor 1) mediates many of HGHs downstream cellular effects, HGH itself acts upstream and triggers a broader signaling cascade

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Figure 1B shows the natural abundance of HDO in the mouse brain before injection of [6,6]- 2 H 2 glucose, which was used as an internal concentration reference