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Depletion of NFS1 cysteine desulfurase in mitochondria reduces the synthesis of iron-sulfur clusters, triggering a feedback response to iron deficiency that increases iron uptake and enhances sensitivity to ferroptosis [161]

However, the endothelial damage observed in ME/CFS patients does not appear to correlate with the usual markers of endothelial dysfunction seen in cardiovascular disease such as increased levels of symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA), and high-sensitivity C-reactive protein (hs-CRP), and reduced levels of arginine and homoarginine (311)

Similarly, circ-BGN can promote resistance to trastuzumab in breast cancer by enhancing OTUB1-mediated SLC7A11 deubiquitylation and alleviating ferroptosis

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Nucleotide sequences and modifications that determine RIG-I/RNA binding and signaling activities