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This could be connected to EMS-induced senescence, endoplasmic reticulum stress, and oxidative stress in CGCs (73, 74)

coli infection induced local changes in the peritoneum alone, not in the plasma or lungs ( Above all, advanced host types of machinery protect cells by detecting and preventing damage due to intrinsic and exogenous inferior substances, such as oxidative stress and toxins ( Keap1-Nrf2 Signaling Pathway The Keap1-Nrf2 regulatory pathway is a key mechanism for preventing cell damage by detecting intrinsic and exogenous stresses, such as oxidative stress, chemotherapy, and radiation, regulating gene expression to modulate various subsequent antioxidant functions ( Figure 2 ) ( via activation of the Keap1-Nrf2 signaling cascade (95)

Recent studies on Alzheimers disease models have demonstrated that hydrogen can mitigate neuroinflammation by inhibiting the NLRP3 inflammasome pathway, thereby reducing the expression of IL-1 and TNF- , and modulating microglial polarization

& Gmeiner, P

Pharmacol., 67: 49-54

These conditions are characterized by chronic relapses and require lifelong treatment, with an increased risk of malignancy, resulting in significant psychological and physiological impacts on patients [1, 2]