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TCR is first recruited through the intracellular structural domains of CD4 and CD8 by lymphocyte cell-specific protein tyrosine kinase (LCK) to phosphorylate immunoreceptor tyrosine activation motifs (ITAM) and activate the tyrosine-protein kinase ZAP-70

It is supported by this hypothesized mechanism by one longitudinal clinical cohort study: serum ROS levels were associated with joint space narrowing and its 5-year progression

Acknowledgements The authors are thankful to Chitkara University, Punjab for providing all the technical facilities for research work

Major preclinical studies: The work of the Sikiric group and collaborators in Zagreb constitutes the most important body of research

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Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes