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Ismail Kimji, MD, FRCPC, as medical reviewer

Liposomal encapsulation wraps GHK-Cu in lipid vesicles that can fuse with the skin barrier, delivering the peptide to deeper layers

doi: 10.1016/j.ghir.2005.05.002 54 SaukkonenTAminRWilliamsRMFoxCYuenKCWhiteMAet al

There is meaningful interest in GHK-Cu for skin regeneration and remodeling, but patients should know the evidence is still not the same as having large, acne-scar-specific human trials proving strong visible improvement in post-Accutane scarring

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Ghrelin, a gastric peptide with potent GH secretagogue properties, amplifies hypothalamic GHRH secretion and synergizes its pituitary GH-stimulation effects ( Insulin Insulin suppresses GH secretion, but the underlying mechanisms are not well-understood, and are postulated to occur at several different levels