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Research on Cu mechanisms in nervous system disorders is active, but discoveries linking Cu dysregulation and DM-related encephalopathy remain largely epidemiological, lacking molecular or mechanistic studies

People with pernicious anemia: An autoimmune condition in which the immune system destroys the stomach cells that produce intrinsic factor, making it impossible to absorb B12 from food or oral supplements

Glutathione peroxidase activity measurements Glutathione peroxidase activity was determined using a Glutathione Peroxidase Assay Kit (Merck Life Science Kft, Budapest, Hungary) according to the manufacturers protocol

Nplate is not a chemotherapy drug

Previous investigations have highlighted elevated NNMT expression in the liver and white adipose tissue (WAT) of diabetic mice and obese, with evidence suggesting that downregulating NNMT expression can mitigate diet-induced IR and obesity (Kraus et al., 2014

Concurrently, studies indicate that Li-ESWT can enhance the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF)