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Peroxisome proliferator-activated receptor gamma (PPAR) is recognized as one of the key metabolic regulators of adipose tissue metabolic homeostasis modulating lipid synthesis, hormonal response, glucose metabolism, and adipokines production among many other functions [5]

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We can only speculate as to whether that is what happens because no urologist has undertaken duplex Doppler testing to obtain images of the area where the plaque went away. We think its feasible that the fibrosis gets better, but the underlying issue from the initial damage still exists and frequently gets worse if Peyronies accelerators start working as a result of aging, etc