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Similar results were observed in another clinical study, in which depressed patients showed increased hsa-miR-342 and reduced hsa-miR-146a and hsa-miR-155 levels in peripheral blood mononuclear cells, with a positive correlation between hsa-miR-342 and TNF- levels ( In an experimental study, a chronic social stress animal model induced depressive-like behaviors in mice and significantly reduced miR-184-3p levels in the neurons of the PVN (Xu et al., 2024)

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An NAD(P)H:quinone oxidoreductase 1 responsive and self-immolative prodrug of 5-fluorouracil for safe and effective cancer therapy

Challenges in the therapy of NeuroHIV As ART alone is insufficient to fully suppress HIV-1 replication, including the transcription and translation of HIV-1 provirus in both T-cell reservoirs and non-CD4 T-cell reservoirs, there is a critical need to develop new brain-penetrating agents that can effectively target both CNS and peripheral immune cells to simultaneously silence HIV-1 and reduce the risk of neuroinflammation

N Engl J Med (2012) 366(4):34859