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Conclusion: Type VII collagen degradation may provide an early indication of metabolic stress associated with enhanced activity of matrix metalloproteinases causing tissue remodeling driving tissue changes during the early stages of NAFLD

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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

10.1016/j.jconrel.2020.05.037 29 CumpelikA.AnkliB.ZecherD.SchifferliJ