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In ME/CFS, in addition to PBMCs, proteomics analyses show that plasma proteins associated with the extracellular matrix, immune system, and cell-cell communication differ significantly from healthy controls

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However, the regulatory mechanism of ferroptosis has not been fully elucidated and the investigation still faces challenges

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While it is difficult to make a clear distinction between the composition of a healthy and unhealthy microbiome, there is consensus that a microbiome dominated by lactic acid producing microbes (mainly of the genus Lactobacillus ), help constitute an acidic and non-diseased state 8