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For lack of selenium, enzyme activity is reduced and, consequently, accumulate in the body 2 peroxides that cause degenerative changes in the myocardium, skeletal muscle, and liver

Gupta et al., a enzyme from a spirochaetes ancestor likely through a novel HGT event, rather than from an -proteobacteria through mitochondria symbiosis (Gray et al., The archaeon MhTyrA from clade II preferred PDH over ADH activity (Figure 3C) and had a non-acidic residue at the 222 position (Figure 2, Figure S1)

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