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doi: 10.1210/jc.2017-02085 12 HuLPCaiHLiQJTangL

Schwarzenegger apparently opted against a mechanical valve, the only permanent solution available at the time of his surgery, because it would have sharply limited his physical activity and capacity to exercise

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Moreover, Ang II stimulates the synthesis and secretion of aldosterone from the adrenal cortex, and aldosterone in turn increases salt and water reabsorption by the distal tubule

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Other immunosuppressants reported as effective options include cyclophosphamide, methotrexate, rituximab, and alemtuzumab