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Ferrigno, B

Fever is caused by circulating endogenous and/or exogenous pyrogens that increase levels of prostaglandin E2 in the hypothalamus

coli revealed that at least some loss of ATP upon HOCl stress is due to conversion of cellular ATP to inorganic polyphosphates (polyP), which by themselves can act like ATP-independent chaperone holdases, effective in stabilizing unfolding proteins and preventing protein aggregation both in vivo and in vitro [282, 283] (Fig

But the two together can be too harsh

Finally, the determination that evidence indicates that exposure to jet fuels leads to neurologic, cognitive, and behavioral outcomes is consistent with the 2003 NRC toxicological assessment that concluded that JP-8 was potentially toxic to the nervous system based on animal data that were available at that time