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10.1016/j.biopha.2018.03.007 100 KhanN.MukhtarH

De novo biosynthesis of GSH is controlled by the rate-limiting enzyme, glutamate-cysteine ligase (GCL, also known as -glutamylcysteine synthetase, -GCS) which consists of a catalytic (heavy) ( -GCSh) and a regulatory (light) subunit ( -GCSl)

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Among them, DNL201, a CNS-penetrant LRRK2 inhibitor, has been shown in preclinical studies to effectively reduce LRRK2 activity and restore lysosomal function