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Therefore, the findings of the present study that investigated the regulation pathways of CHAC1 probably contributed to elucidation of the induction mechanisms of ferroptosis and the future discovery of therapeutic targets of numerous ischemic injuries

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peak plasma levels of urolithin A and its metabolites only reach about 110 ng/mL (equivalent to 1.2 M) even after direct supplementation with 500 mg of urolithin A in healthy adults (28)