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Schomerus, H

Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP (Haas et al., 2007)

Injecting MTX into carnitine-depleted rats achieved 66% and 99.5% elevation in serum ALT and AST, respectively, compared with the control, and 34% elevation compared with the MTX group

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