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Notably, antioxidant treatment with N-acetylcysteine (NAC) reversed these abnormalities in metabolic syndrome rat hearts [44]

Furthermore, the apoptosis of SGNs detected by C-CASP3 immunostaining and western blot showed that there was much less C-CASP3-positive SGNs and remarkable reduction of the C-CASP3 protein levels in the NAC co-treated groups compared with the peroxynitrite-only groups, and it was also lower in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figures 7B,C)

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Tissue-specific induction of cytochromes p450 1a1 and 1b1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered c57bl/6j mice of arylhydrocarbon receptor gene

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With respect to microbiome-based interventions, microbiome-informed risk profiles may eventually serve as both a screening tool and a guide for intervention selection and success