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Detailed discussion of these pathways goes beyond the scope of this article, and the following serves as an overview and highlight of recent in-depth reviews on this topic

This steep Ca 2+ gradient creates a strong driving force for Ca 2+ entry and is maintained by the low Ca 2+ permeability of the resting erythrocyte and high Ca 2+ -extruding capacity through a Ca 2+ ATPase and Na + /Ca 2+ exchanger in the cell membrane

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ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

Future research should focus on the cellular and molecular mechanisms associated with neurodegenerative diseases to identify more effective diagnostic and therapeutic targets

[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Satarug S., Gobe G.C., Vesey D.A