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Indeed, GSH, Trx, Grx, Prx (together with the enzymes catalyzing their reduction), and the enzymatic antioxidant defense, as a whole, concur to modulate either ROS concentration, or the availability of cellular thiols, thus regulating the function of a large number of proteins implicated in the induction and/or execution of redox-sensitive pathways

J Pharm Pharmacol 2002

Studies have indicated that the expression of Nrf2 and its pathway is associated with the staging and grading of kidney cancer, as well as resistance to targeted therapies and poor prognoses (247, 248)

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We are grateful to all the experts who have joined from different universities all over Egypt to help achieve this huge task in a limited time

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