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Another focus of 2024 will be continuing our work in environmental and social governance

Glut1 drives multidrug resistance through dual mechanisms: upregulating drug efflux pumps (P-gp, MRP) to maintain subtherapeutic intracellular drug concentrations and elevating the Bcl-2/Bax ratio to enhance anti-apoptosis capacity

Serine is a small, neutral amino acid and can be imported into the cell by Na + -dependent transporters like ASCT1 ( SLC1A4 ), which is upregulated in both breast cancer (Pollari et al., 2011) and lung cancer (Riscal et al., 2016), system A transporters like SNAT1 ( SLC38A1 ), and the ASC system (El-Hattab, 2016)

The secondary endpoints include achievement of 20% weight reduction, relative change in body weight, change in waist circumference, change in HbA1c, change in systolic blood pressure, change in the quality of life (IWQOL-Lite-CT), and change in short-form physical functioning score (SF-36v2)

Rationale and design of REDUCE-IT: Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial

Hum Behav Emerg Technol