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doi: 10.1093/oxfordjournals.pcp.a078265 86 TalaatN

Clearly, a reduction in MTHFR activity can alter DNA methylation, with research suggesting that individuals who are homozygous for the polymorphism (C677T) in the MTHFR gene have significantly lower levels of methylated DNA when their folate levels are also low

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doi: 10.3389/fmicb.2026.1800520 Received 31 January 2026 Revised 18 March 2026 Accepted 19 March 2026 Published 15 April 2026 Volume 17 - 2026 Edited by Saba Miri, Humber College, Canada Reviewed by Xia He, Nanchang University, China Salma Younas, University of the Punjab, Pakistan Updates Copyright 2026 Yu, Zhao, Tao and Li