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The results showed that the ointment significantly reduced the damaged area on the rats skin and decreased the expression levels of proteins such as Alpha-Smooth Muscle Actin, Phosphorylated Extracellular Signal-Regulated Kinase 1/2, Phosphorylated Janus Kinase 2, Phosphorylated Signal Transducer and Activator of Transcription 3, and Phosphorylated Protein Kinase B

Its pathological basis is synovitis, initially manifested as morning stiffness, swelling, and pain in small joints such as hands and feet, which can progress to joint deformities and disability [143]

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Montsk, G., Tarjnyi, Z., Mezosi, E

For very hydrophobic peptides the combined ether washes were re-extracted with DMF, allowed to precipitate peptide, and filtered to recover additional peptide

More specifically, in the phthalimide part, the phenyl group is solvent-exposed, while one of the carbonyl groups forms the water-mediated hydrogen bond with His359 21