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RCT 60 hospitalized patients showing that oral N-acetylcysteine (NAC) at 1800mg daily significantly decreased plasma TNF- levels and increased glutathione peroxidase levels

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Often called the master antioxidant, it plays a critical role in neutralizing harmful free radicals, reducing oxidative stress, and protecting cells from damage

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Once the initial monoubiquitination is catalyzed by RNF8, another E3 ligase RNF168 will subsequently participate to transmit the repair signal (Doil et al