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Since Nrf2 participates in the resolution of inflammation by repressing genes for proinflammatory cytokines IL-6 and IL-1 (Kobayashi et al., 2016

This inactive form of glutathione can be recycled back into GSH with the help of an enzyme called glutathione reductase

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In mammalian cells, ER stress leads to an integrated stress response involving the related transmembrane kinases Ire1, Ire1 and PKRlike ER kinase (PERK), and the transmembrane activating transcription factor 6 (ATF6) (Zhang & Kaufman, 2004)

Because the majority of factors that cause foot swelling also may cause ankle swelling, this article will discuss swelling as a general topic to cover both foot and ankle swelling